Skip to main content

Bus from Portsmouth, OH to Lake City, FL

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
Explore now

Enjoy free onboard entertainment

Watch a FREE movie and use our power outlets to stay powered up during your trip.
Find out what’s playing

Reserve a Seat

Reserve your favorite seat when you book your ticket.
Window or Aisle?

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.
Discover all your options

On this page

Bus stations and stops in Portsmouth, OH

Please note: your ticket will contain the most up-to-date address information.

Discover all the places you can go

Choose from almost 2,300 destinations with Greyhound, FlixBus and our connecting partners!

Frequently asked questions

There are up to one Greyhound bus operating daily from Portsmouth to Lake City. Check the schedule by entering your travel date in the search box above.
The travel time from Portsmouth to Lake City by bus is approximately 31 hours 5 minutes, covering a distance of about 1266 miles. The fastest route includes .
You can check the status of your Greyhound bus traveling from Portsmouth to Lake City by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.
For your trip from Portsmouth to Lake City, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.
Traveling by Greyhound from Portsmouth to Lake City is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.
On Greyhound buses from Portsmouth to Lake City, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.
The earliest bus from Portsmouth to Lake City departs at 2:10 am.
The latest bus from Portsmouth to Lake City leaves at 2:10 am.
Yes, you can book both Greyhound and FlixBus tickets for travel from Portsmouth to Lake City on our website. Simply enter your travel details to compare schedules and fares.
Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from Portsmouth to Lake City in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.
The locations of Greyhound bus stops in Portsmouth and Lake City can be found on this page, along with detailed maps and addresses.

Looking for Greyhound Bus Tickets from Portsmouth to Lake City?

How to Book Your Bus Trip to Lake City from Portsmouth

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Portsmouth to Lake City, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Lake City, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability