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Bus from Columbia, MO to Panama City, FL

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Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.
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Bus stations and stops in Columbia, MO

Please note: your ticket will contain the most up-to-date address information.

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Frequently asked questions

Yes, on this website you can book both Greyhound and FlixBus tickets from Columbia to Panama City. You can check both the Greyhound and FlixBus ride schedules once you select your departure city, destination city, and desired trip date.
The bus trip from Columbia to Panama City is about 1085 miles long. The quickest trip with Greyhound takes 27 hours.
Greyhound runs up to 2 rides per day from Columbia to Panama City. You can search for your preferred departure date and check the schedule using the search bar above.
You can track the status of your Columbia to Panama City bus using Greyhound's bus tracker. With this tool, you can see the real-time location of your bus and get updates on its departure and arrival times.
The first Greyhound bus to Panama City from Columbia leaves at 8:30 am.
Onboard services available on Greyhound buses from Columbia to Panama City include free Wi-Fi for all passengers, personal power outlets near every seat, reclining leather seats with footrests, extra legroom, overhead storage, and an on-board restroom.
The last Greyhound bus to Panama City from Columbia leaves at 8:35 pm.
When traveling on the bus from Columbia to Panama City with Greyhound, you can bring one carry-on bag with you (maximum 25 lbs, 16x12x7 inches). You can store one bag under the bus for free, and if you have a Flexible fare, the second bag stored under the bus is also free. You can also carry additional or bulky baggage for a supplementary charge. You can reserve extra baggage while booking your ticket on our website or app. Alternatively, you can add bulky items later through the 'Manage My Booking' section. If your departure is from a location with Greyhound personnel, you can book and pay for your extra luggage there. For more information, please refer to our baggage policy page here.
Traveling by bus from Columbia to Panama City with Greyhound is a convenient and environmentally responsible choice, as bus travel reduces traffic and emissions compared to traveling by car.
Greyhound buses are equipped with wheelchair lifts to assist passengers using wheelchairs or mobility scooters. Each bus has space for two passengers with these devices. It's recommended to book your bus from Columbia to Panama City in advance to ensure a spot. If you'd like to transfer to a regular seat, our drivers will stow your device for you. Service animals are also welcome on board our buses. For further details on accessibility and service animal policies, please check this link.
You can easily find the locations and addresses of the bus stops in Columbia and in Panama City on this page: check the address and their location on the map!
  • Columbia has 2 bus stop(s), namely: Columbia (Midway Travel Plaza), Columbia (Wabash Station)
  • Panama City has 1 bus stop(s), namely: Panama City Beach Bus Station

Plan your bus trip from Columbia to Panama City with Greyhound

The first bus departs at 8:30 am and the last bus departs at 8:35 pm. Greyhound operates 2 bus rides daily between Columbia and Panama City. When traveling with Greyhound to Panama City from Columbia, expect free Wifi, power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Panama City in seconds.

How to Book Your Bus Ticket to Panama City from Columbia

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Columbia to Panama City, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Panama City, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability