Skip to main content

Bus from Des Moines, IA to Louisville, KY

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
Explore now

Enjoy free onboard entertainment

Watch a FREE movie and use our power outlets to stay powered up during your trip.
Find out what’s playing

Reserve a Seat

Reserve your favorite seat when you book your ticket.
Window or Aisle?

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.
Discover all your options

On this page

Bus stations and stops in Des Moines, IA

Please note: your ticket will contain the most up-to-date address information.

Discover all the places you can go

Choose from almost 2,300 destinations with Greyhound, FlixBus and our connecting partners!

Frequently asked questions

With Greyhound and FlixBus, you can conveniently reach 26 destinations from Louisville, including Chicago, Indianapolis, Nashville.
Yes, night trip options are available from Des Moines to Louisville. Check out the route's schedule and choose the best option to suit your plans!
The bus trip from Des Moines to Louisville is about 596 miles long. The quickest trip with Greyhound takes 13 hours 50 minutes.
You can track the status of your Des Moines to Louisville bus using Greyhound's bus tracker. With this tool, you can see the real-time location of your bus and get updates on its departure and arrival times.
When traveling on the bus from Des Moines to Louisville with Greyhound, you can bring one carry-on bag with you (maximum 25 lbs, 16x12x7 inches). You can store one bag under the bus for free, and if you have a Flexible fare, the second bag stored under the bus is also free. You can also carry additional or bulky baggage for a supplementary charge. You can reserve extra baggage while booking your ticket on our website or app. Alternatively, you can add bulky items later through the 'Manage My Booking' section. If your departure is from a location with Greyhound personnel, you can book and pay for your extra luggage there. For more information, please refer to our baggage policy page here.
Traveling by bus from Des Moines to Louisville with Greyhound is a convenient and environmentally responsible choice, as bus travel reduces traffic and emissions compared to traveling by car.
Onboard services available on Greyhound buses from Des Moines to Louisville include free Wi-Fi for all passengers, personal power outlets near every seat, reclining leather seats with footrests, extra legroom, overhead storage, and an on-board restroom.
The first Greyhound bus to Louisville from Des Moines leaves at 5:30 am.
The last Greyhound bus to Louisville from Des Moines leaves at 11:45 pm.
Yes, on this website you can book both Greyhound and FlixBus tickets from Des Moines to Louisville. You can check both the Greyhound and FlixBus ride schedules once you select your departure city, destination city, and desired trip date.
Greyhound runs up to 3 rides per day from Des Moines to Louisville. You can search for your preferred departure date and check the schedule using the search bar above.
Greyhound buses are equipped with wheelchair lifts to assist passengers using wheelchairs or mobility scooters. Each bus has space for two passengers with these devices. It's recommended to book your bus from Des Moines to Louisville in advance to ensure a spot. If you'd like to transfer to a regular seat, our drivers will stow your device for you. Service animals are also welcome on board our buses. For further details on accessibility and service animal policies, please check this link.
You can easily find the bus stops in Des Moines and in Louisville on this page: check the address and their location on the map!
The Des Moines to Louisville bus starts from $95.99. Booking in advance, whether on the app or website, is the best way to get the most affordable bus travel. If you book online, you can choose to pay with a debit card or credit card on the Greyhound app or website. If you prefer, you can also pay in person with cash.

Plan your bus trip from Des Moines to Louisville with Greyhound

The trip from Des Moines to Louisville takes as short as 13 hours 50 minutes and could cost as little as $95.99. The first bus departs at 5:30 am and the last bus departs at 11:45 pm. Greyhound operates 3 bus rides daily between Des Moines and Louisville. When traveling with Greyhound to Louisville from Des Moines, expect free Wifi, power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Louisville in seconds.

How to Book Your Bus Ticket to Louisville from Des Moines

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Des Moines to Louisville, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Louisville, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability