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Bus from Mesa, AZ to San Ysidro, CA

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Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.
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Bus stations and stops in Mesa, AZ

Please note: your ticket will contain the most up-to-date address information.

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Frequently asked questions

Bus tickets from Mesa to San Ysidro start at $68.98. To get the best deals, book your tickets in advance through our app or website. Payment options include debit or credit cards online, or cash at certain locations.
The travel time from Mesa to San Ysidro by bus is approximately 12 hours 30 minutes, covering a distance of about 541 miles.
You can check the status of your Greyhound bus traveling from Mesa to San Ysidro by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.
For your trip from Mesa to San Ysidro, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.
Traveling by Greyhound from Mesa to San Ysidro is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.
On Greyhound buses from Mesa to San Ysidro, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.
The earliest bus from Mesa to San Ysidro departs at 1:45 pm.
The latest bus from Mesa to San Ysidro leaves at 8:10 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from Mesa to San Ysidro on our website. Simply enter your travel details to compare schedules and fares.
There are up to one Greyhound bus operating daily from Mesa to San Ysidro. Check the schedule by entering your travel date in the search box above.
Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from Mesa to San Ysidro in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.
The locations of Greyhound bus stops in Mesa and San Ysidro can be found on this page, along with detailed maps and addresses.

Planning Your Greyhound Bus Trip from Mesa to San Ysidro?

The journey from Mesa to San Ysidro can take as little as 12 hours 30 minutes and starts from as little as $68.98. The earliest bus leaves at 1:45 pm and the last bus leaves at 8:10 pm. Greyhound provides daily buses Mesa to San Ysidro from Mesa to San Ysidro. Travel with Greyhound and enjoy complimentary Wifi, access to power sockets, and a comfortable seat throughout your trip. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to San Ysidro in seconds.

How to Book Your Bus Ticket to San Ysidro from Mesa

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Mesa to San Ysidro, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to San Ysidro, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability