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Bus from Panama City, FL to Key West, FL

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You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
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Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.
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Reserve a Seat

Reserve your favorite seat when you book your ticket.
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Need to make a change?

Easily change your ticket or add bags with Manage My Booking.
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Bus stations and stops in Panama City, FL

Please note: your ticket will contain the most up-to-date address information.

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Frequently asked questions

You can check the status of your Greyhound bus traveling from Panama City to Key West by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.
The travel time from Panama City to Key West by bus is approximately 26 hours 40 minutes, covering a distance of about 835 miles.
Bus tickets from Panama City to Key West start at $99.98. To get the best deals, book your tickets in advance through our app or website. Payment options include debit or credit cards online, or cash at certain locations.
For your trip from Panama City to Key West, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.
Traveling by Greyhound from Panama City to Key West is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.
On Greyhound buses from Panama City to Key West, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.
The earliest bus from Panama City to Key West departs at 12:50 pm.
The latest bus from Panama City to Key West leaves at 12:50 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from Panama City to Key West on our website. Simply enter your travel details to compare schedules and fares.
There are up to one Greyhound bus operating daily from Panama City to Key West. Check the schedule by entering your travel date in the search box above.
Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from Panama City to Key West in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.
The locations of Greyhound bus stops in Panama City and Key West can be found on this page, along with detailed maps and addresses.

Looking for Greyhound Bus Tickets from Panama City to Key West?

Your search ends here! We've got all the info you need to plan your bus journey. The trip from Panama City to Key West can be as quick as 26 hours 40 minutes and as cost-effective as $99.98. The first bus of the day departs at 12:50 pm. Greyhound runs daily buses Panama City to Key West between Panama City and Key West. Traveling with Greyhound guarantees free Wifi, access to power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Key West in seconds.

How to Book Your Bus Trip to Key West from Panama City

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Panama City to Key West, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Key West, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability