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Bus from Pittsburgh, PA to Buffalo, NY

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More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
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Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.
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Reserve a Seat

Reserve your favorite seat when you book your ticket.
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Need to make a change?

Easily change your ticket or add bags with Manage My Booking.
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Bus stations and stops in Pittsburgh, PA

Please note: your ticket will contain the most up-to-date address information.

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Choose from almost 2,300 destinations with Greyhound, FlixBus and our connecting partners!

Frequently asked questions

Onboard amenities on Greyhound buses from Pittsburgh to Buffalo include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
The first Greyhound bus from Pittsburgh to Buffalo departs at 4:55 am.
The last Greyhound bus from Pittsburgh to Buffalo leaves at 1:45 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from Pittsburgh to Buffalo through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.
Greyhound operates up to 1 trip daily from Pittsburgh to Buffalo. You can find the schedule by entering your departure date in the search box above.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from Pittsburgh to Buffalo in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
You can find the Greyhound bus stops in both Pittsburgh and Buffalo by checking the map on this page, which shows the addresses and locations of all stops.
Opting for Greyhound to travel from Pittsburgh to Buffalo is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
The journey by Greyhound bus from Pittsburgh to Buffalo covers approximately 289 miles. The quickest trip takes 7 hours 15 minutes.
Bus tickets from Pittsburgh to Buffalo start at $35.98. For the best rates, it is recommended to book in advance via our app or website. You can pay online using debit or credit cards, or choose to pay in person with cash at selected locations.
To track your bus from Pittsburgh to Buffalo, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
When traveling from Pittsburgh to Buffalo with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.

Onboard services are subject to availability