Skip to main content

Bus from Port St. Lucie, FL to Frederick, MD

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
Explore now

Enjoy free onboard entertainment

Watch a FREE movie and use our power outlets to stay powered up during your trip.
Find out what’s playing

Reserve a Seat

Reserve your favorite seat when you book your ticket.
Window or Aisle?

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.
Discover all your options

On this page

Bus stations and stops in Port St. Lucie, FL

Please note: your ticket will contain the most up-to-date address information.

Discover all the places you can go

Choose from almost 2,300 destinations with Greyhound, FlixBus and our connecting partners!

Frequently asked questions

The journey by Greyhound bus from Port St. Lucie to Frederick covers approximately 1189 miles. The quickest trip duration is 31 hours 5 minutes, .
Bus tickets from Port St. Lucie to Frederick start at $151.99. For the best rates, it is recommended to book in advance via our app or website. You can pay online using debit or credit cards, or choose to pay in person with cash at selected locations.
To track your bus from Port St. Lucie to Frederick, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
When traveling from Port St. Lucie to Frederick with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.
Opting for Greyhound to travel from Port St. Lucie to Frederick is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
Onboard amenities on Greyhound buses from Port St. Lucie to Frederick include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
The first Greyhound bus from Port St. Lucie to Frederick departs at 1:40 am.
The last Greyhound bus from Port St. Lucie to Frederick leaves at 3:20 am.
Yes, you can book both Greyhound and FlixBus tickets for travel from Port St. Lucie to Frederick through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.
Greyhound operates up to 2 trips daily from Port St. Lucie to Frederick. You can find the schedule by entering your departure date in the search box above.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from Port St. Lucie to Frederick in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
You can find the Greyhound bus stops in both Port St. Lucie and Frederick by checking the map on this page, which shows the addresses and locations of all stops.

Planning Your Greyhound Bus Trip from Port St. Lucie to Frederick?

The journey from Port St. Lucie to Frederick can take as little as 31 hours 5 minutes and starts from as little as $151.99. The earliest bus leaves at 1:40 am and the last bus leaves at 3:20 am. Greyhound schedules 2 buses per day from Port St. Lucie to Frederick. Travel with Greyhound and enjoy complimentary Wifi, access to power sockets, and a comfortable seat throughout your trip. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Frederick in seconds.

How to Book Your Bus Ticket to Frederick from Port St. Lucie

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Port St. Lucie to Frederick, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Frederick, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability