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Bus from Port St. Lucie, FL to Louisville, KY

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Bus stations and stops in Port St. Lucie, FL

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Frequently asked questions

There are up to 3 Greyhound buses operating daily from Port St. Lucie to Louisville. Check the schedule by entering your travel date in the search box above.
The travel time from Port St. Lucie to Louisville by bus is approximately 24 hours 10 minutes, covering a distance of about 1022 miles. The fastest route includes .
You can check the status of your Greyhound bus traveling from Port St. Lucie to Louisville by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.
For your trip from Port St. Lucie to Louisville, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.
Traveling by Greyhound from Port St. Lucie to Louisville is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.
On Greyhound buses from Port St. Lucie to Louisville, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.
The earliest bus from Port St. Lucie to Louisville departs at 1:40 am.
The latest bus from Port St. Lucie to Louisville leaves at 8:55 am.
Yes, you can book both Greyhound and FlixBus tickets for travel from Port St. Lucie to Louisville on our website. Simply enter your travel details to compare schedules and fares.
Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from Port St. Lucie to Louisville in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.
The locations of Greyhound bus stops in Port St. Lucie and Louisville can be found on this page, along with detailed maps and addresses.

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How to Book Your Bus Trip to Louisville from Port St. Lucie

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Port St. Lucie to Louisville, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Louisville, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability