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Bus from Port St. Lucie, FL to San Diego, CA

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Bus stations and stops in Port St. Lucie, FL

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Frequently asked questions

There are up to 6 Greyhound buses operating daily from Port St. Lucie to San Diego. Check the schedule by entering your travel date in the search box above.
The travel time from Port St. Lucie to San Diego by bus is approximately 64 hours 5 minutes, covering a distance of about 2888 miles. The fastest route includes .
Bus tickets from Port St. Lucie to San Diego start at $208.99. To get the best deals, book your tickets in advance through our app or website. Payment options include debit or credit cards online, or cash at certain locations.
You can check the status of your Greyhound bus traveling from Port St. Lucie to San Diego by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.
For your trip from Port St. Lucie to San Diego, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.
Traveling by Greyhound from Port St. Lucie to San Diego is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.
On Greyhound buses from Port St. Lucie to San Diego, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.
The earliest bus from Port St. Lucie to San Diego departs at 1:40 am.
The latest bus from Port St. Lucie to San Diego leaves at 3:40 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from Port St. Lucie to San Diego on our website. Simply enter your travel details to compare schedules and fares.
Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from Port St. Lucie to San Diego in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.
The locations of Greyhound bus stops in Port St. Lucie and San Diego can be found on this page, along with detailed maps and addresses.

Planning Your Greyhound Bus Trip from Port St. Lucie to San Diego?

The journey from Port St. Lucie to San Diego can take as little as 64 hours 5 minutes and starts from as little as $208.99. The earliest bus leaves at 1:40 am and the last bus leaves at 3:40 pm. Greyhound schedules 6 buses per day from Port St. Lucie to San Diego. Travel with Greyhound and enjoy complimentary Wifi, access to power sockets, and a comfortable seat throughout your trip. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to San Diego in seconds.

How to Book Your Bus Ticket to San Diego from Port St. Lucie

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Port St. Lucie to San Diego, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to San Diego, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability