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Bus from Rochester, NY to Panama City, FL

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Bus stations and stops in Rochester, NY

Please note: your ticket will contain the most up-to-date address information.

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Frequently asked questions

The Greyhound bus ride from Rochester to Panama City takes around 42 hours 45 minutes, covering a distance of approximately 1729 miles. The fastest route involves .
To track your Greyhound bus from Rochester to Panama City, use our bus tracker. It provides real-time updates on your bus’s location and expected arrival times.
For your trip from Rochester to Panama City, Greyhound allows one carry-on bag (up to 25 lbs, 16x12x7 inches) and one checked bag for free. If you have a Flexible fare, you can also check a second bag at no additional cost. Extra or oversized baggage can be added during booking or later via "Manage My Booking." Certain locations allow in-person payment for extra luggage. More details are available on our baggage policy page
Choosing Greyhound for your journey from Rochester to Panama City is an eco-conscious option, helping to reduce emissions and traffic compared to traveling by car.
Greyhound buses from Rochester to Panama City offer free Wi-Fi, power outlets at each seat, reclining seats with extra legroom, overhead storage, and onboard restrooms.
The first bus from Rochester to Panama City departs at 1:15 pm.
The last bus from Rochester to Panama City departs at 6:55 pm.
Yes, you can book tickets for both Greyhound and FlixBus from Rochester to Panama City on our website. After entering your travel details, you can compare schedules and fares for both options.
There are up to 2 daily Greyhound bus trips from Rochester to Panama City. Use the search tool above to check the schedule.
Greyhound buses are equipped with wheelchair lifts and spaces for passengers using mobility devices. We recommend booking your trip from Rochester to Panama City in advance. Service animals are welcome on all Greyhound buses. For more information, please visit our accessibility page.
You can find the bus stops for Greyhound in both Rochester and Panama City by viewing the map on this page, which includes addresses and locations of all stops.

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How to Book Your Bus Trip to Panama City from Rochester

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Rochester to Panama City, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Panama City, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability