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Bus from Sioux Falls, SD to Greenville, SC

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Bus stations and stops in Sioux Falls, SD

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Frequently asked questions

There are up to one Greyhound bus operating daily from Sioux Falls to Greenville. Check the schedule by entering your travel date in the search box above.
The travel time from Sioux Falls to Greenville by bus is approximately 35 hours 30 minutes, covering a distance of about 1395 miles. The fastest route includes .
You can check the status of your Greyhound bus traveling from Sioux Falls to Greenville by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.
For your trip from Sioux Falls to Greenville, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.
Traveling by Greyhound from Sioux Falls to Greenville is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.
On Greyhound buses from Sioux Falls to Greenville, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.
The earliest bus from Sioux Falls to Greenville departs at 8:05 pm.
The latest bus from Sioux Falls to Greenville leaves at 8:05 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from Sioux Falls to Greenville on our website. Simply enter your travel details to compare schedules and fares.
Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from Sioux Falls to Greenville in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.
The locations of Greyhound bus stops in Sioux Falls and Greenville can be found on this page, along with detailed maps and addresses.

Planning Your Greyhound Bus Trip from Sioux Falls to Greenville?

How to Book Your Bus Ticket to Greenville from Sioux Falls

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Sioux Falls to Greenville, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Greenville, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability