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Bus from St Louis, MO to Des Moines, IA

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Bus stations and stops in St Louis, MO

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Frequently asked questions

The journey by Greyhound bus from St Louis to Des Moines covers approximately 390 miles. The quickest trip duration is 10 hours 15 minutes, .
Bus tickets from St Louis to Des Moines start at $77.99. For the best rates, it is recommended to book in advance via our app or website. You can pay online using debit or credit cards, or choose to pay in person with cash at selected locations.
To track your bus from St Louis to Des Moines, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
When traveling from St Louis to Des Moines with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.
Opting for Greyhound to travel from St Louis to Des Moines is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
Onboard amenities on Greyhound buses from St Louis to Des Moines include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
The first Greyhound bus from St Louis to Des Moines departs at 1:30 am.
The last Greyhound bus from St Louis to Des Moines leaves at 11:15 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from St Louis to Des Moines through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.
Greyhound operates up to 3 trips daily from St Louis to Des Moines. You can find the schedule by entering your departure date in the search box above.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from St Louis to Des Moines in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
You can find the Greyhound bus stops in both St Louis and Des Moines by checking the map on this page, which shows the addresses and locations of all stops.

Planning Your Greyhound Bus Trip from St Louis to Des Moines?

The journey from St Louis to Des Moines can take as little as 10 hours 15 minutes and starts from as little as $77.99. The earliest bus leaves at 1:30 am and the last bus leaves at 11:15 pm. Greyhound schedules 3 buses per day from St Louis to Des Moines. Travel with Greyhound and enjoy complimentary Wifi, access to power sockets, and a comfortable seat throughout your trip. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Des Moines in seconds.

How to Book Your Bus Ticket to Des Moines from St Louis

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from St Louis to Des Moines, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Des Moines, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability