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Bus from St Louis, MO to San Diego, CA

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Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.
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Bus stations and stops in St. Louis, MO

Please note: your ticket will contain the most up-to-date address information.

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Frequently asked questions

To track your Greyhound bus from St. Louis to San Diego, use our bus tracker. It provides real-time updates on your bus’s location and expected arrival times.
The Greyhound bus ride from St. Louis to San Diego takes around 40 hours, covering a distance of approximately 1909 miles.
A bus ticket from St. Louis to San Diego starts at $155.98. For the cheapest rates, it’s best to book in advance through our app or website. You can pay online with a debit or credit card, or in cash at select locations.
For your trip from St. Louis to San Diego, Greyhound allows one carry-on bag (up to 25 lbs, 16x12x7 inches) and one checked bag for free. If you have a Flexible fare, you can also check a second bag at no additional cost. Extra or oversized baggage can be added during booking or later via "Manage My Booking." Certain locations allow in-person payment for extra luggage. More details are available on our baggage policy page
Choosing Greyhound for your journey from St. Louis to San Diego is an eco-conscious option, helping to reduce emissions and traffic compared to traveling by car.
Greyhound buses from St. Louis to San Diego offer free Wi-Fi, power outlets at each seat, reclining seats with extra legroom, overhead storage, and onboard restrooms.
The first bus from St. Louis to San Diego departs at 1:35 am.
The last bus from St. Louis to San Diego departs at 4:30 pm.
Yes, you can book tickets for both Greyhound and FlixBus from St. Louis to San Diego on our website. After entering your travel details, you can compare schedules and fares for both options.
There are up to 6 daily Greyhound bus trips from St. Louis to San Diego. Use the search tool above to check the schedule.
Greyhound buses are equipped with wheelchair lifts and spaces for passengers using mobility devices. We recommend booking your trip from St. Louis to San Diego in advance. Service animals are welcome on all Greyhound buses. For more information, please visit our accessibility page.
You can find the bus stops for Greyhound in both St. Louis and San Diego by viewing the map on this page, which includes addresses and locations of all stops.

Plan your bus trip from St. Louis to San Diego with Greyhound

The trip from St. Louis to San Diego takes as short as 40 hours and could cost as little as $155.98. The first bus departs at 1:35 am and the last bus departs at 4:30 pm. Greyhound operates 6 bus rides daily between St. Louis and San Diego. When traveling with Greyhound to San Diego from St. Louis, expect free Wifi, power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to San Diego in seconds.

How to Book Your Bus Ticket to San Diego from St. Louis

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from St. Louis to San Diego, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to San Diego, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability