Skip to main content

Bus from Tupelo, MS to Myrtle Beach, SC

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
Explore now

Enjoy free onboard entertainment

Watch a FREE movie and use our power outlets to stay powered up during your trip.
Find out what’s playing

Reserve a Seat

Reserve your favorite seat when you book your ticket.
Window or Aisle?

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.
Discover all your options

On this page

Bus stations and stops in Tupelo, MS

Please note: your ticket will contain the most up-to-date address information.

Discover all the places you can go

Choose from almost 2,300 destinations with Greyhound, FlixBus and our connecting partners!

Frequently asked questions

The Greyhound bus ride from Tupelo to Myrtle Beach takes around 21 hours, covering a distance of approximately 669 miles. The fastest route involves .
A bus ticket from Tupelo to Myrtle Beach starts at $120.99. For the cheapest rates, it’s best to book in advance through our app or website. You can pay online with a debit or credit card, or in cash at select locations.
To track your Greyhound bus from Tupelo to Myrtle Beach, use our bus tracker. It provides real-time updates on your bus’s location and expected arrival times.
For your trip from Tupelo to Myrtle Beach, Greyhound allows one carry-on bag (up to 25 lbs, 16x12x7 inches) and one checked bag for free. If you have a Flexible fare, you can also check a second bag at no additional cost. Extra or oversized baggage can be added during booking or later via "Manage My Booking." Certain locations allow in-person payment for extra luggage. More details are available on our baggage policy page
Choosing Greyhound for your journey from Tupelo to Myrtle Beach is an eco-conscious option, helping to reduce emissions and traffic compared to traveling by car.
Greyhound buses from Tupelo to Myrtle Beach offer free Wi-Fi, power outlets at each seat, reclining seats with extra legroom, overhead storage, and onboard restrooms.
The first bus from Tupelo to Myrtle Beach departs at 1:30 pm.
The last bus from Tupelo to Myrtle Beach departs at 11:15 pm.
Yes, you can book tickets for both Greyhound and FlixBus from Tupelo to Myrtle Beach on our website. After entering your travel details, you can compare schedules and fares for both options.
There are up to 2 daily Greyhound bus trips from Tupelo to Myrtle Beach. Use the search tool above to check the schedule.
Greyhound buses are equipped with wheelchair lifts and spaces for passengers using mobility devices. We recommend booking your trip from Tupelo to Myrtle Beach in advance. Service animals are welcome on all Greyhound buses. For more information, please visit our accessibility page.
You can find the bus stops for Greyhound in both Tupelo and Myrtle Beach by viewing the map on this page, which includes addresses and locations of all stops.

Looking for Greyhound Bus Tickets from Tupelo to Myrtle Beach?

Your search ends here! We've got all the info you need to plan your bus journey. The trip from Tupelo to Myrtle Beach can be as quick as 21 hours and as cost-effective as $120.99. The first bus of the day departs at 1:30 pm and the last bus departs at 11:15 pm. Greyhound offers 2 buses daily between Tupelo and Myrtle Beach. Traveling with Greyhound guarantees free Wifi, access to power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Myrtle Beach in seconds.

How to Book Your Bus Trip to Myrtle Beach from Tupelo

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Tupelo to Myrtle Beach, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Myrtle Beach, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability