Skip to main content

Bus from Tampa, FL to Knoxville, TN

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
Explore now

Enjoy free onboard entertainment

Watch a FREE movie and use our power outlets to stay powered up during your trip.
Find out what’s playing

Reserve a Seat

Reserve your favorite seat when you book your ticket.
Window or Aisle?

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.
Discover all your options

On this page

Bus stations and stops in Tampa, FL

Please note: your ticket will contain the most up-to-date address information.

Discover all the places you can go

Choose from almost 2,300 destinations with Greyhound, FlixBus and our connecting partners!

Frequently asked questions

There are up to one Greyhound bus operating daily from Tampa to Knoxville. Check the schedule by entering your travel date in the search box above.
The travel time from Tampa to Knoxville by bus is approximately 21 hours 40 minutes, covering a distance of about 749 miles. The fastest route includes .
Bus tickets from Tampa to Knoxville start at $129.99. To get the best deals, book your tickets in advance through our app or website. Payment options include debit or credit cards online, or cash at certain locations.
You can check the status of your Greyhound bus traveling from Tampa to Knoxville by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.
For your trip from Tampa to Knoxville, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.
Traveling by Greyhound from Tampa to Knoxville is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.
On Greyhound buses from Tampa to Knoxville, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.
The earliest bus from Tampa to Knoxville departs at 12:40 am.
The latest bus from Tampa to Knoxville leaves at 10:25 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from Tampa to Knoxville on our website. Simply enter your travel details to compare schedules and fares.
Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from Tampa to Knoxville in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.
The locations of Greyhound bus stops in Tampa and Knoxville can be found on this page, along with detailed maps and addresses.

Looking for Greyhound Bus Tickets from Tampa to Knoxville?

Your search ends here! We've got all the info you need to plan your bus journey. The trip from Tampa to Knoxville can be as quick as 21 hours 40 minutes and as cost-effective as $129.99. The first bus of the day departs at 12:40 am and the last bus departs at 10:25 pm. Greyhound runs daily buses Tampa to Knoxville between Tampa and Knoxville. Traveling with Greyhound guarantees free Wifi, access to power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Knoxville in seconds.

How to Book Your Bus Trip to Knoxville from Tampa

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Tampa to Knoxville, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Knoxville, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability