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Bus from Knoxville, TN to Sioux Falls, SD

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We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.
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Bus stations and stops in Knoxville, TN

Please note: your ticket will contain the most up-to-date address information.

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Frequently asked questions

Onboard amenities on Greyhound buses from Knoxville to Sioux Falls include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
The first Greyhound bus from Knoxville to Sioux Falls departs at 10:15 pm.
The last Greyhound bus from Knoxville to Sioux Falls leaves at 10:15 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from Knoxville to Sioux Falls through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.
Greyhound operates up to 1 trip daily from Knoxville to Sioux Falls. You can find the schedule by entering your departure date in the search box above.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from Knoxville to Sioux Falls in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
You can find the Greyhound bus stops in both Knoxville and Sioux Falls by checking the map on this page, which shows the addresses and locations of all stops.
Opting for Greyhound to travel from Knoxville to Sioux Falls is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
The journey by Greyhound bus from Knoxville to Sioux Falls covers approximately 1397 miles. The quickest trip takes 35 hours 50 minutes.
Bus tickets from Knoxville to Sioux Falls start at $150.98. For the best rates, it is recommended to book in advance via our app or website. You can pay online using debit or credit cards, or choose to pay in person with cash at selected locations.
To track your bus from Knoxville to Sioux Falls, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
When traveling from Knoxville to Sioux Falls with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.

Planning Your Greyhound Bus Trip from Knoxville to Sioux Falls?

The journey from Knoxville to Sioux Falls can take as little as 35 hours 50 minutes and starts from as little as $150.98. The earliest bus leaves at 10:15 pm. Greyhound provides daily buses Knoxville to Sioux Falls from Knoxville to Sioux Falls. Travel with Greyhound and enjoy complimentary Wifi, access to power sockets, and a comfortable seat throughout your trip. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Sioux Falls in seconds.

How to Book Your Bus Ticket to Sioux Falls from Knoxville

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Knoxville to Sioux Falls, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Sioux Falls, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability