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Bus from Portland, ME to North Charleston, SC

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.

Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.

Reserve a Seat

Reserve your favorite seat when you book your ticket.

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.

On this page

Bus stations and stops in Portland, ME

Please note: your ticket will contain the most up-to-date address information.
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Free WiFi
Stay connected throughout your journey
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Power Outlets
Keep your devices charged on the go
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Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
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Toilets
Conveniently available on every FlixBus
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Frequently asked questions

You can find the bus stops for Greyhound in both Portland and North Charleston by viewing the map on this page, which includes addresses and locations of all stops.
The Greyhound bus ride from Portland to North Charleston takes around 28 hours 45 minutes, covering a distance of approximately 1159 miles.
To track your Greyhound bus from Portland to North Charleston, use our bus tracker. It provides real-time updates on your bus’s location and expected arrival times.
For your trip from Portland to North Charleston, Greyhound allows one carry-on bag (up to 25 lbs, 16x12x7 inches) and one checked bag for free. If you have a Flexible fare, you can also check a second bag at no additional cost. Extra or oversized baggage can be added during booking or later via "Manage My Booking." Certain locations allow in-person payment for extra luggage. More details are available on our baggage policy page
Choosing Greyhound for your journey from Portland to North Charleston is an eco-conscious option, helping to reduce emissions and traffic compared to traveling by car.
Greyhound buses from Portland to North Charleston offer free Wi-Fi, power outlets at each seat, reclining seats with extra legroom, overhead storage, and onboard restrooms.
The first bus from Portland to North Charleston departs at 1:45 pm.
The last bus from Portland to North Charleston departs at 1:45 pm.
Yes, you can book tickets for both Greyhound and FlixBus from Portland to North Charleston on our website. After entering your travel details, you can compare schedules and fares for both options.
There are up to one daily Greyhound bus trip from Portland to North Charleston. Use the search tool above to check the schedule.
Greyhound buses are equipped with wheelchair lifts and spaces for passengers using mobility devices. We recommend booking your trip from Portland to North Charleston in advance. Service animals are welcome on all Greyhound buses. For more information, please visit our accessibility page.

Looking for Greyhound Bus Tickets from Portland to North Charleston?

How to Book Your Bus Trip to North Charleston from Portland

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Portland to North Charleston, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to North Charleston, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability