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Bus from San Antonio, TX to Lake City, FL

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You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
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Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.
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Reserve a Seat

Reserve your favorite seat when you book your ticket.
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Need to make a change?

Easily change your ticket or add bags with Manage My Booking.
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Bus stations and stops in San Antonio, TX

Please note: your ticket will contain the most up-to-date address information.

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Choose from almost 2,300 destinations with Greyhound, FlixBus and our connecting partners!

Frequently asked questions

You can check the status of your Greyhound bus traveling from San Antonio to Lake City by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.
The travel time from San Antonio to Lake City by bus is approximately 24 hours 15 minutes, covering a distance of about 1031 miles.
Bus tickets from San Antonio to Lake City start at $93.98. To get the best deals, book your tickets in advance through our app or website. Payment options include debit or credit cards online, or cash at certain locations.
For your trip from San Antonio to Lake City, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.
Traveling by Greyhound from San Antonio to Lake City is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.
On Greyhound buses from San Antonio to Lake City, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.
The earliest bus from San Antonio to Lake City departs at 7:45 am.
The latest bus from San Antonio to Lake City leaves at 4:45 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from San Antonio to Lake City on our website. Simply enter your travel details to compare schedules and fares.
There are up to one Greyhound bus operating daily from San Antonio to Lake City. Check the schedule by entering your travel date in the search box above.
Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from San Antonio to Lake City in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.
The locations of Greyhound bus stops in San Antonio and Lake City can be found on this page, along with detailed maps and addresses.

Looking for Greyhound Bus Tickets from San Antonio to Lake City?

Your search ends here! We've got all the info you need to plan your bus journey. The trip from San Antonio to Lake City can be as quick as 24 hours 15 minutes and as cost-effective as $93.98. The first bus of the day departs at 7:45 am and the last bus departs at 4:45 pm. Greyhound runs daily buses San Antonio to Lake City between San Antonio and Lake City. Traveling with Greyhound guarantees free Wifi, access to power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Lake City in seconds.

How to Book Your Bus Trip to Lake City from San Antonio

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from San Antonio to Lake City, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Lake City, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability