Skip to main content

Bus from Santa Cruz, CA to San Ysidro, CA

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
Explore now

Enjoy free onboard entertainment

Watch a FREE movie and use our power outlets to stay powered up during your trip.
Find out what’s playing

Reserve a Seat

Reserve your favorite seat when you book your ticket.
Window or Aisle?

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.
Discover all your options

On this page

Bus stations and stops in Santa Cruz, CA

Please note: your ticket will contain the most up-to-date address information.

Discover all the places you can go

Choose from almost 2,300 destinations with Greyhound, FlixBus and our connecting partners!

Frequently asked questions

The Greyhound bus ride from Santa Cruz to San Ysidro takes around 17 hours 45 minutes, covering a distance of approximately 541 miles. The fastest route involves .
To track your Greyhound bus from Santa Cruz to San Ysidro, use our bus tracker. It provides real-time updates on your bus’s location and expected arrival times.
For your trip from Santa Cruz to San Ysidro, Greyhound allows one carry-on bag (up to 25 lbs, 16x12x7 inches) and one checked bag for free. If you have a Flexible fare, you can also check a second bag at no additional cost. Extra or oversized baggage can be added during booking or later via "Manage My Booking." Certain locations allow in-person payment for extra luggage. More details are available on our baggage policy page
Choosing Greyhound for your journey from Santa Cruz to San Ysidro is an eco-conscious option, helping to reduce emissions and traffic compared to traveling by car.
Greyhound buses from Santa Cruz to San Ysidro offer free Wi-Fi, power outlets at each seat, reclining seats with extra legroom, overhead storage, and onboard restrooms.
The first bus from Santa Cruz to San Ysidro departs at 6:40 am.
The last bus from Santa Cruz to San Ysidro departs at 6:40 am.
Yes, you can book tickets for both Greyhound and FlixBus from Santa Cruz to San Ysidro on our website. After entering your travel details, you can compare schedules and fares for both options.
There are up to one daily Greyhound bus trip from Santa Cruz to San Ysidro. Use the search tool above to check the schedule.
Greyhound buses are equipped with wheelchair lifts and spaces for passengers using mobility devices. We recommend booking your trip from Santa Cruz to San Ysidro in advance. Service animals are welcome on all Greyhound buses. For more information, please visit our accessibility page.
You can find the bus stops for Greyhound in both Santa Cruz and San Ysidro by viewing the map on this page, which includes addresses and locations of all stops.

Plan your bus trip from Santa Cruz to San Ysidro with Greyhound

The first bus departs at 6:40 am. Greyhound offers daily bus rides from Santa Cruz to San Ysidro. When traveling with Greyhound to San Ysidro from Santa Cruz, expect free Wifi, power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to San Ysidro in seconds.

How to Book Your Bus Ticket to San Ysidro from Santa Cruz

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Santa Cruz to San Ysidro, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to San Ysidro, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability