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Bus from Orange County-Anaheim-Santa Ana, CA to San Francisco, CA

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More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
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Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.
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Reserve a Seat

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Need to make a change?

Easily change your ticket or add bags with Manage My Booking.
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Bus stations and stops in Orange County-Anaheim-Santa Ana, CA

Please note: your ticket will contain the most up-to-date address information.

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Choose from almost 2,300 destinations with Greyhound, FlixBus and our connecting partners!

Frequently asked questions

You can check the status of your Greyhound bus traveling from Orange County-Anaheim-Santa Ana to San Francisco by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.
The travel time from Orange County-Anaheim-Santa Ana to San Francisco by bus is approximately 8 hours 45 minutes, covering a distance of about 429 miles.
Bus tickets from Orange County-Anaheim-Santa Ana to San Francisco start at $59.98. To get the best deals, book your tickets in advance through our app or website. Payment options include debit or credit cards online, or cash at certain locations.
For your trip from Orange County-Anaheim-Santa Ana to San Francisco, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.
Traveling by Greyhound from Orange County-Anaheim-Santa Ana to San Francisco is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.
On Greyhound buses from Orange County-Anaheim-Santa Ana to San Francisco, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.
The earliest bus from Orange County-Anaheim-Santa Ana to San Francisco departs at 7:25 am.
The latest bus from Orange County-Anaheim-Santa Ana to San Francisco leaves at 10:35 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from Orange County-Anaheim-Santa Ana to San Francisco on our website. Simply enter your travel details to compare schedules and fares.
There are up to 4 Greyhound buses operating daily from Orange County-Anaheim-Santa Ana to San Francisco. Check the schedule by entering your travel date in the search box above.
Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from Orange County-Anaheim-Santa Ana to San Francisco in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.
The locations of Greyhound bus stops in Orange County-Anaheim-Santa Ana and San Francisco can be found on this page, along with detailed maps and addresses.

Onboard services are subject to availability