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Bus from Port St. Lucie, FL to Panama City, FL

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Bus stations and stops in Port St. Lucie, FL

Please note: your ticket will contain the most up-to-date address information.

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Frequently asked questions

The Greyhound bus ride from Port St. Lucie to Panama City takes around 12 hours, covering a distance of approximately 507 miles. The fastest route involves .
A bus ticket from Port St. Lucie to Panama City starts at $126.99. For the cheapest rates, it’s best to book in advance through our app or website. You can pay online with a debit or credit card, or in cash at select locations.
To track your Greyhound bus from Port St. Lucie to Panama City, use our bus tracker. It provides real-time updates on your bus’s location and expected arrival times.
For your trip from Port St. Lucie to Panama City, Greyhound allows one carry-on bag (up to 25 lbs, 16x12x7 inches) and one checked bag for free. If you have a Flexible fare, you can also check a second bag at no additional cost. Extra or oversized baggage can be added during booking or later via "Manage My Booking." Certain locations allow in-person payment for extra luggage. More details are available on our baggage policy page
Choosing Greyhound for your journey from Port St. Lucie to Panama City is an eco-conscious option, helping to reduce emissions and traffic compared to traveling by car.
Greyhound buses from Port St. Lucie to Panama City offer free Wi-Fi, power outlets at each seat, reclining seats with extra legroom, overhead storage, and onboard restrooms.
The first bus from Port St. Lucie to Panama City departs at 1:40 am.
The last bus from Port St. Lucie to Panama City departs at 1:40 am.
Yes, you can book tickets for both Greyhound and FlixBus from Port St. Lucie to Panama City on our website. After entering your travel details, you can compare schedules and fares for both options.
There are up to one daily Greyhound bus trip from Port St. Lucie to Panama City. Use the search tool above to check the schedule.
Greyhound buses are equipped with wheelchair lifts and spaces for passengers using mobility devices. We recommend booking your trip from Port St. Lucie to Panama City in advance. Service animals are welcome on all Greyhound buses. For more information, please visit our accessibility page.
You can find the bus stops for Greyhound in both Port St. Lucie and Panama City by viewing the map on this page, which includes addresses and locations of all stops.

Looking for Greyhound Bus Tickets from Port St. Lucie to Panama City?

Your search ends here! We've got all the info you need to plan your bus journey. The trip from Port St. Lucie to Panama City can be as quick as 12 hours and as cost-effective as $126.99. The first bus of the day departs at 1:40 am. Greyhound runs daily buses Port St. Lucie to Panama City between Port St. Lucie and Panama City. Traveling with Greyhound guarantees free Wifi, access to power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Panama City in seconds.

How to Book Your Bus Trip to Panama City from Port St. Lucie

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Port St. Lucie to Panama City, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Panama City, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability